反应详情

Into 12 ml of chloroform was dissolved 1.39 g of 5-benzyloxy-3-methylthio-1,2,4-thiadiazole, and metachloroperbenzoic acid (>70%) was slowly added to the mixture under ice-cooling. After stirring for 1 hour, the compound of low-polarity from the reaction mixture was detected by thin layer chromatography. The reaction mixture was poured into a saturated sodium sulfite aqueous solution, and separated. The organic layer was washed with sodium hydrogen carbonate aqueous solution, dried over anhydrous sodium sulfate, concentrated to give 1.4 g of 5-benzyloxy-3-methylsulfinyl-1,2,4-thiadiazole.

1. additionwas slowly added to the mixture under ice-
2. temperaturecooling
3. customseparated
4. washThe organic layer was washed with sodium hydrogen carbonate aqueous solution
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated