反应详情

(E)-7-(2,5-dimethoxy-3,4,6-trimethylphenyl)-5-methylhept-5-en-1-ol in pyridine (2 mL) was treated with Ac2O (2 mL) at 0° C. and let stir overnight. The reaction was quenched with H2O (10 mL) followed by addition of EtOAc (10 mL) and separated. The aqueous phase was extracted with EtOAc (3×10 mL) and the combined organics washed with brine (15 mL), dried over anhydrous Na2SO4 and concentrated to a yellow oil. Flash chromatography on silica yielded 77.9 mg (62.3%) of (E)-7-(2,5-dimethoxy-3,4,6-trimethylphenyl)-5-methylhept-5-enyl acetate as a clear oil.

1. customThe reaction was quenched with H2O (10 mL)
2. additionfollowed by addition of EtOAc (10 mL)
3. customseparated
4. extractionThe aqueous phase was extracted with EtOAc (3×10 mL)
5. washthe combined organics washed with brine (15 mL)
6. dry with materialdried over anhydrous Na2SO4
7. concentrationconcentrated to a yellow oil