反应详情

温度

50 °C

To a 50 mL RB flask fitted with magnetic stirrer was charged 10 mL of acetonitrile. To the stirred solvent was added 2-cyano-3-(4-hydroxy-phenyl)-propanoic acid methyl ester (0.3 g, 1.57 mmol), followed by K2CO3 (0.65 g, 4.71 mmol) and 3-bromomethyl-phenol (0.294 g, 1.57 mmol). After addition, the RM was heated at 50° C. for 1 h. After 1 h, the RM was concentrated to distill off the solvent, water (20 mL) was added and the aqueous layer was extracted with ethyl acetate (15 mL×2). The organic layer was dried over anhydrous Na2SO4. The solvent was removed under reduced pressure. The product was obtained as yellow liquid. (0.32 g, yield: 65.44%); MS (ESI, 120 eV): m/z=310.0 (M−H)+.

1. customTo a 50 mL RB flask fitted with magnetic stirrer
2. additionAfter addition
3. concentrationthe RM was concentrated
4. distillationto distill off the solvent, water (20 mL)
5. additionwas added
6. extractionthe aqueous layer was extracted with ethyl acetate (15 mL×2)
7. dry with materialThe organic layer was dried over anhydrous Na2SO4
8. customThe solvent was removed under reduced pressure
9. customThe product was obtained as yellow liquid