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HRID923040

反应详情

EQUATION

反应方程式

HRID 923040 的结构方程式

REACTANTS

反应物

5
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：O=C(O)c1ccc(S(=O)(=O)Cl)cc1
HCID82385

Benzoic acid, 4-(chlorosulfonyl)-

C7H5ClO4S

结构：CC(C)(C)OC(=O)N1CCNCC1
HCID143452

tert-Butyl piperazine-1-carboxylate

C9H18N2O2

结构：CC(C)(C)OC(=O)N1CCN(S(=O)(=O)c2ccc(C(=O)O)cc2)CC1
HCID15169652

4-[4-(tert-Butoxycarbonyl)piperazine-1-sulfonyl]benzoic acid

C16H22N2O6S

结构：Nc1ccc(Cl)c(-c2ccccn2)c1
HCID40151925

4-Chloro-3-(pyridin-2-yl)aniline

C11H9ClN2

PRODUCTS

生成物

1
结构：O=C(Nc1ccc(Cl)c(-c2ccccn2)c1)c1ccc(S(=O)(=O)N2CCNCC2)cc1
HCID58614943

未命名化合物

PROCEDURE

实验过程

1 g of 4-(chlorosulfonyl)benzoic acid was reacted with 931 mg of tert-butyl piperazine-1-carboxylate via Procedure H. 75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 150 mg of 4-(4-(tert-butoxycarbonyl)piperazin-1-ylsulfonyl)benzoic acid via Procedure G. The crude product was subjected to basic workup conditions, treated with TFA to remove the Boc group and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(piperazin-1-ylsulfonyl)benzamide. MS (Q1) 457.1 (M)+.

WORKUP

后处理

  1. customto remove the Boc group
  2. custompurified by reverse phase HPLC