反应详情

To a solution of tert-butyl [(3S)-1-(5-nitro-2,3-dihydrofuro[2,3-b]pyridin-4-yl)piperidin-3-yl]carbamate (411.2 mg, 1.128 mmol) in MeOH (5.00 mL) under a nitrogen atmosphere was added 10% Pd on carbon (108.7 mg, 0.1021 mmol). The reaction mixture was hydrogenated at 1 atm. for 14 h. The mixture was then filtered through a pad of diatomaceous earth (eluted with MeOH). The filtrate was concentrated under reduced pressure to give the sub-title compound as an off-white solid (387.9 mg) which was used directly in the next step without further purification. LCMS calc. for C17H27N4O3 (M+H)+: m/z=335.2. found 335.2.

1. filtrationThe mixture was then filtered through a pad of diatomaceous earth (eluted with MeOH)
2. concentrationThe filtrate was concentrated under reduced pressure