反应详情

To a solution of ethyl 2-(thiophen-3-yl)acetate (2.3 g, 16.2 mmol) in anhydrous THF (20 mL) was added LiHMDS (19.4 mL, 19.44 mmol) at −78° C. After stirring at that temperature for 0.5 h, a solution of nicotinoyl chloride (2.8 g, 16.2 mmol) in anhydrous THF (10 mL) was added into the reaction mixture and stirred at −78° C. for 4 hours. The mixture was quenched with NH4Cl solution, extracted with EtOAc. The organic layer was concentrated in vacuo and purified by silica gel column chromatography (1.7 g, yield 38%).

1. stirringstirred at −78° C. for 4 hours
2. customThe mixture was quenched with NH4Cl solution
3. extractionextracted with EtOAc
4. concentrationThe organic layer was concentrated in vacuo
5. custompurified by silica gel column chromatography (1.7 g, yield 38%)