反应详情

To {4-[5-Methyl-1-(tetrahydro-pyran-2-yl)-3-trifluoromethyl-1H-pyrazol-4-yl]-phenyl}-acetonitrile (Example 8B) (35 mg, 0.1 mmol, 1.0 equiv) in ethyl acetate (1 ml) was added HCl in ethyl acetate (1 ml) and the mixture was stirred for 1 hour. The solvents were removed under reduced pressure and the title compound was purified by column chromatography (SiO2) eluting with a linear gradient (0-30% ethyl acetate-petrol) 16 mg (60%); LCMS (PS-A) Rt 2.85 min [M+H]+ 266.

1. customThe solvents were removed under reduced pressure
2. customthe title compound was purified by column chromatography (SiO2)
3. washeluting with a linear gradient (0-30% ethyl acetate-petrol) 16 mg (60%)