反应详情

温度

0 °C

N′-(2-ethylphenyl)-N-(2-ethylphenyl)acetamidine (NS Amidine I) (0.798 g, 3.0 mmol) was dissolved in 50 mL of diethylether and cooled to 0° C. Butyllithium (1.50 mL of 2.0 M solution in pentane, 3.0 mmol) was added dropwise, producing a light yellow solution. The solution was warmed to room temperature and stirred for 2 hours. Chlorodiisopropylphosphine (0.48 mL, 3.0 mmol) was added slowly at room temperature. A white suspension formed, which was stirred overnight at room temperature. The slurry was filtered to remove a small amount of white solid, presumably lithium chloride, and the solvent was removed in vacuo to produce 1.14 g (99%) of yellow oil.

1. customproducing a light yellow solution
2. temperatureThe solution was warmed to room temperature
3. customA white suspension formed
4. stirringwhich was stirred overnight at room temperature
5. filtrationThe slurry was filtered
6. customto remove a small amount of white solid, presumably lithium chloride
7. customthe solvent was removed in vacuo