反应详情

In a 10 mL round-bottomed flask, (S)-methyl 3-(4-(allyloxy)-3-chlorophenyl)-2-(tert-butoxycarbonylamino)propanoate (90 mg, 243 μmol, Eq: 1.00) was combined with formic acid (1.12 g, 933 μL, 24.3 mmol, Eq: 100) and stirred at RT for 3 h. The crude reaction mixture was concentrated in vacuo. The reaction mixture was neutralised with 5% aqueous Na2CO3 and extracted with DCM (3×). The organic layers were combined and dried over Na2SO4 and concentrated in vacuo to yield a colorless oil (68 mg; 100%). m/z=270.3 [M+H]+; 292.1 [M+Na]+.

1. customThe crude reaction mixture
2. concentrationwas concentrated in vacuo
3. extractionextracted with DCM (3×)
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo
6. customto yield a colorless oil (68 mg; 100%)