反应详情

A mixture of [5-({[1-(4-Hydroxymethyl-benzyl)-1H-pyrazole-4-carbonyl]-amino}-methyl)-4,6-dimethyl-pyridin-2-yl]-carbamic acid tert-butyl ester (100 mg, 0.2 mmol, for preparation see step D, example 16), trimethylsilyl chloride (47 mg, 0.4 mmol) and DMSO (4 mg, 0.06 mmol) was stirred at RT for 10 min. Aq. NaHCO3-solution was added and the mixture was extracted with ethyl acetate. The organic layer was dried over MgSO4 and concentrated in vacuo to yield the title compound which was used in the next step without further purification. LCMS (method A) RtA=1.598 min; [M+H]+=484.0.

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialThe organic layer was dried over MgSO4
3. concentrationconcentrated in vacuo