反应详情

A mixture of N-([1,1′-biphenyl]-2-yl)-6-cyclohexyl-N-(4-methoxyphenyl)dibenzo[b,d]furan-4-amine (8.9 g, 17.0 mmol) and pyridine hydrochloride (19.6 g, 170.0 mmol) was purged with nitrogen overnight. The mixture was then refluxed for 2 h. After cooling, the precipitate was filtered and washed by excess water. The residue was purified by flash chromatography using 90% DCM/hexane (containing 1% triethylamine) to yield 4-([1,1′-biphenyl]-2-yl(6-cyclohexyldibenzo[b,d]furan-4-yl)amino)phenol (6.5 g, 75% yield) as a white solid.

1. customwas purged with nitrogen overnight
2. temperatureThe mixture was then refluxed for 2 h
3. temperatureAfter cooling
4. filtrationthe precipitate was filtered
5. washwashed by excess water
6. customThe residue was purified by flash chromatography