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HRID929951

反应详情

EQUATION

反应方程式

HRID 929951 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)[Si](C)(C)OCCCBr
HCID607486

(3-Bromopropoxy)-tert-butyldimethylsilane

C9H21BrOSi

结构：COC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C
HCID7016055

Boc-D-Tyr-OMe

C15H21NO5

PRODUCTS

生成物

1
结构：CC(C)(C)[Si](C)(C)OCCCOc1ccc([C@@H]2OC(=O)N[C@H]2CO[Si](C)(C)C(C)(C)C)cc1
HCID86718533

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCCCCCC.CCOC(C)=O
溶剂HCID21899848

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to the procedure described for intermediate 12 starting with (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanoate and (3-bromopropoxy)(tert-butyl)dimethylsilane. TLC (heptane/EtOAc 1:1) Rf=0.49; tR=1.832 min (UPLC 1); LC-MS: [M+H] 496; Rt 1.62 min (LC-MS method 1); 1H NMR (400 MHz, CDCl3): 7.30 (d, 2H), 6.95 (d, 2H), 5.27 (br s, 1H), 5.22 (d, 1H), 4.13 (dd, 2H), 4.00 (m, 2H), 3.80 (m, 3H), 3.74 (m, 2H), 2.01 (m, 2H), 0.93 (s, 9H), 0.91 (s, 9H), 0.10 (s, 6H), 0.06 (s, 6H).