HRID931238

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID89853794

未命名化合物

PRODUCTS

生成物

结构：O=C([C@@H]1CCCN(c2ccc3nc(-c4nccc(C5CC5)n4)[nH]c3n2)C1)N1CCOCC1

HCID178521023

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by a method analogous to the one used for Example 95, but using (R)-(1-(5,6-diaminopyridin-2-yl)piperidin-3-yl)(morpholino)methanone dihydrochloride (synthesized by hydrogenation analogous to the one used for Intermediate 1, starting from Intermediate 40) and Intermediate 42. MS (ES+APCI) (M+H) 434.2; LCMS retention time 1.996 min (Method G).

WORKUP

后处理

customsynthesized by hydrogenation analogous to the one

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8130070eb213406ab6afc8a2e507cf95
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09296745B2
来源说明: uspto-grants-2016_03

反应 SMILES

Cl.Cl.[NH2:3][C:4]1[CH:5]=[CH:6][C:7]([N:11]2[CH2:16][CH2:15][CH2:14][C@@H:13]([C:17]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[O:18])[CH2:12]2)=[N:8][C:9]=1[NH2:10].Cl.Cl.NC1C=[CH:30][C:31]([N:35]2[CH2:40][CH2:39][CH2:38][C@@H:37]([C:41](N3CCCC3)=O)[CH2:36]2)=[N:32]C=1N.NC1N=C(N2CCC[C@@H](C(N3CCOCC3)=O)C2)C=CC=1[N+]([O-])=O.C1(C2C=CN=C(C(=N)OCC)N=2)CC1>>[CH:37]1([C:38]2[CH:39]=[CH:40][N:35]=[C:31]([C:30]3[NH:10][C:9]4=[N:8][C:7]([N:11]5[CH2:16][CH2:15][CH2:14][C@@H:13]([C:17]([N:19]6[CH2:20][CH2:21][O:22][CH2:23][CH2:24]6)=[O:18])[CH2:12]5)=[CH:6][CH:5]=[C:4]4[N:3]=3)[N:32]=2)[CH2:36][CH2:41]1