反应详情

温度

20 °C

A mixture of 4-(aminomethyl)-N-(3-pyridinyl)benzamide (33) (256 mg, 1.1 mmol) and 2-thienylsulfonyl chloride (206 mg, 1.1 mmol) in dry pyridine (10 mL) was stirred at 20° C. for 16 h. The solvent was evaporated and the residue stirred in ice/water (20 mL) for 1 h. The precipitate was filtered, washed with water (5 mL) and dried. The crude solid was purified by column chromatography, eluting with EtOAc, to give benzamide I-4 (318 mg, 75%) as a white powder: mp (EtOAc) 185-188° C.; 1H NMR δ 10.38 (s, 1H, NHCO), 8.93 (d, J=2.2 Hz, 1H, H-2″), 8.46 (br s, 1H, NHSO2), 8.31 (dd, J=4.7, 1.5 Hz, 1H, H-6″), 8.19 (ddd, J=8.2, 2.5, 1.5 Hz, 1H, H-4″), 7.90-7.95 (m, 3H, H-2, H-6, H-5′), 7.61 (dd, J=3.7, 1.3 Hz, 1H, H-3′), 7.43 (br d, J=8.3 Hz, 2H, H-3, H-5), 7.39 (ddd, J=8.2, 4.7, 0.5 Hz, 1H, H-5″), 7.18 (dd, J=5.0, 3.7 Hz, 1H, H-4′), 4.17 (s, 2H, CH2N); 13C NMR δ 165.4, 144.4, 141.9, 141.5, 141.4, 135.7, 133.0, 132.4, 131.5, 127.6 (2), 127.5, 127.3 (2), 127.2, 123.4, 45.8; MS m/z 374.6 (MH+, 100%). Anal. calcd for C17H15N3O3S2: C, 54.67; H, 4.05; N, 11.25. Found: C, 55.23; H, 4.11; N, 11.32%.

1. customThe solvent was evaporated
2. stirringthe residue stirred in ice/water (20 mL) for 1 h
3. filtrationThe precipitate was filtered
4. washwashed with water (5 mL)
5. customdried
6. customThe crude solid was purified by column chromatography
7. washeluting with EtOAc