反应详情

To a solution of 2-((9-amino-7-bromo-4-fluoro-2-methoxy-9H-xanthen-9-yl)methoxy)acetonitrile (7.72 g, 19.63 mmol) in DCE (115 mL) was added trimethylaluminum (2M in toluene) (19.63 mL, 39.3 mmol) at RT. The reaction mixture was stirred for 10 min at RT and then heated to 75° C. for 1 hour. The reaction mixture was cooled to RT and quenched with sodium sulfate decahydrate. The reaction mixture was vigorously stirred for 30 minutes, diluted with EtOAc and stirred overnight. The mixture was filtered through a pad of celite and filter cake was washed with EtOAc. The solvent was removed under reduced pressure to obtain an oily residue which crystallized to give 7′-bromo-4′-fluoro-2′-methoxy-2,6-dihydrospiro[[1,4]oxazine-3,9′-xanthen]-5-amine (7.49 g, 19.05 mmol, 97% yield) as a cream-colored solid.

1. temperatureheated to 75° C. for 1 hour
2. temperatureThe reaction mixture was cooled to RT
3. customquenched with sodium sulfate decahydrate
4. stirringThe reaction mixture was vigorously stirred for 30 minutes
5. additiondiluted with EtOAc
6. stirringstirred overnight
7. filtrationThe mixture was filtered through a pad of celite
8. filtrationfilter cake
9. washwas washed with EtOAc
10. customThe solvent was removed under reduced pressure
11. customto obtain an oily residue which
12. customcrystallized