反应详情

温度

80 °C

Acetic anhydride was added to a flask containing (S)-6-(1-tert-butoxy-2-ethoxy-2-oxoethyl)-5-(4-chlorophenyl)-2,7-dimethylquinoline 1-oxide (compound of Example 14) (42 mg, 0.095 mmol). The mixture was stirred at 80° C. for 1 hour. Acetic anhydride was removed under vacuum. The residue was dissolved in ethyl acetate (50 mL). The organic layer was washed with NaHCO3 solution and water, dried and concentrated in vacuo. The obtained residue was used for next step reaction without purification. LCMS-ESI+ (m/z): 484.2, 486.2 (M+H)+.

1. customAcetic anhydride was removed under vacuum
2. dissolutionThe residue was dissolved in ethyl acetate (50 mL)
3. washThe organic layer was washed with NaHCO3 solution and water
4. customdried
5. concentrationconcentrated in vacuo
6. customThe obtained residue was used for next step reaction without purification