反应详情

2-(5-(Biphenyl-4-yl)-2,7-dimethylquinolin-6-yl)-2-tert-butoxyacetic acid was prepared following the procedure used to prepare compound (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-((methyl(phenyl)amino) methyl)quinolin-6-yl)acetic acid of Example 14, except that ethyl 2-(5-(biphenyl-4-yl)-2,7-dimethylquinolin-6-yl)-2-tert-butoxyacetate was used instead of (S)-ethyl 2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(methyl(phenyl)amino)methyl)quinolin-6-yl)acetate. 1H-NMR 300 MHz, (CD3OD) 8.40 (d, 1H), 7.96 (s, 1H), 7.95-7.90 (m, 2H), 7.70-7.60 (m, 4H), 7.55-7.40 (m, 4H), 5.39 (s, 1H), 2.96 (s, 3H), 2.80 (s, 3H), 0.98 (s, 9H); LCMS-ESI+ (m/z): [M+H]+ calcd for C29H30NO3: 440.6. Found: 440.2.