反应详情

(S)-2-tert-Butoxy-2-(6-(4-chlorophenyl)-8-methylimidazo[1,2-a]quinolin-7-yl)acetic acid (62) was prepared in a similar manner as compound (S)-2-tert-butoxy-2-((R)-6-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-isopropyl-8-methylimidazo[1,2-a]quinolin-7-yl)acetic acid of Example 60 except using (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(trifluoromethylsulfonyloxy)quinolin-6-yl)ethyl pivalate and 2,2-dimethoxyethanamine instead of (S)-2-tert-butoxy-2-((R)-5-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-7-methyl-2-(trifluoromethylsulfonyloxy)quinolin-6-yl)ethyl pivalate and (S)-1,1-dimethoxy-3-methylbutan-2-amine. 1H-NMR 400 MHz (CD3OD) δ 8.92 (m, 1 H), 8.45 (m, 1 H), 8.10 (m, 1 H), 7.7-7.6 (m, 5 H), 7.38 (m, 1 H), 5.21 (s, 1 H), 2.80 (s, 3 H), 0.99 (s, 9 H); LCMS-ESI+ (m/z): [M+H]+ calcd for C24H24ClN2O3: 423. Found: 423.2; LCMS-ESI+ (m/z): [M+H]+ calcd for C24H22ClN2O3: 421.1. Found: 421.0.