HCID 66631939, compound → (S)-2-tert-butoxy-2-(6-(4-chlorophenyl)-8-methyltetrazolo[1,5-a]quinolin-7-yl)ethanol

HRID 931807Notes

Reaction equation

HRID 931807 reaction equation
C(OC[C@@H](OC(C)(C)C)C1C(C2C=CC(Cl)=CC=2)=C2C(=CC=1C)N=C(N1CCOCC1)C=C2)(=O)C(C)(C)C.C([O:45][CH2:46][C@@H:47]([O:69][C:70]([CH3:73])([CH3:72])[CH3:71])[C:48]1[C:49]([C:62]2[CH:67]=[CH:66][C:65]([Cl:68])=[CH:64][CH:63]=2)=[C:50]2[C:55](=[CH:56][C:57]=1[CH3:58])[N:54]1[N:59]=[N:60][N:61]=[C:53]1[CH:52]=[CH:51]2)(=O)C(C)(C)C>>[C:70]([O:69][C@@H:47]([C:48]1[C:49]([C:62]2[CH:67]=[CH:66][C:65]([Cl:68])=[CH:64][CH:63]=2)=[C:50]2[C:55](=[CH:56][C:57]=1[CH3:58])[N:54]1[N:59]=[N:60][N:61]=[C:53]1[CH:52]=[CH:51]2)[CH2:46][OH:45])([CH3:73])([CH3:71])[CH3:72]

Participants

3

Reactant 2

HCID 66631939HCID 66631939, compoundHCID 66633692(S)-2-tert-butoxy-2-(6-(4-chlorophenyl)-8-methyltetrazolo[1,5-a]quinolin-7-yl)ethyl pivalate

Product 1

HCID 66633654(S)-2-tert-butoxy-2-(6-(4-chlorophenyl)-8-methyltetrazolo[1,5-a]quinolin-7-yl)ethanol

Procedure

(S)-2-tert-butoxy-2-(6-(4-chlorophenyl)-8-methyltetrazolo[1,5-a]quinolin-7-yl)ethanol (5 mg) was prepared in a similar manner as compound ((S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-morpholinoquinolin-6-yl)ethanol of Example 29 except using (S)-2-tert-butoxy-2-(6-(4-chlorophenyl)-8-methyltetrazolo[1,5-a]quinolin-7-yl)ethyl pivalate instead of (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-morpholinoquinolin-6-yl)ethyl pivalate. LCMS-ESI+ (m/z): [M+H]+ calcd for C22H24ClN4O2: 411.2. Found: 411.1.

Sources & evidence

ORD record
ord-d7af1a9008414af398d025f150fe8371
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

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