反应详情

(S)-2-tert-Butoxy-2-(5-(4-chlorophenyl)-2-methoxy-7-methylquinolin-6-yl)acetic acid (66) (2.3 mg) was prepared in a similar manner as compound (S)-2-(2-(benzyloxy)-5-(4-chlorophenyl)-7-methylquinolin-6-yl)-2-tert-butoxyacetic acid of Example 65 except using iodomethane instead of benzyl bromide. 1H-NMR 400 MHz (CD3OD) δ 7.68 (s, 1 H), 7.6-7.5 (m, 4 H), 7.30 (d, J=8 Hz, 1 H), 6.87 (d, J=9.6 Hz, 1H), 5.16 (s, 1 H), 4.08 (s, 3 H), 2.62 (s, 3 H), 0.97 (s, 9 H); LCMS-ESI+ (m/z): [M+H]+ calcd for C23H25ClNO4: 414.1. Found: 414.2; LCMS-ESI+ (m/z): [M+H]+ calcd for C23H23ClNO4: 412.1. Found: 412.0.