反应详情

(S)-2-tert-Butoxy-2-(5-(4-chlorophenyl)-1,7-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)acetic acid (67) (2.0 mg) was prepared in a similar manner as compound (S)-2-(1-benzyl-5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-tert-butoxyacetic acid of Example 65 except using iodomethane instead of benzyl bromide. 1H-NMR 400 MHz (CD3OD) δ 7.6-7.5 (m, 4 H), 7.3-7.26 (m, 2 H), 6.49 (d, J=10 Hz, 1 H), 5.06 (s, 1 H), 3.78 (s, 3 H), 2.64 (s, 3 H), 0.97 (s, 9 H); LCMS-ESI+ (m/z): [M+H]+ calcd for C23H25ClNO4: 414.1. Found: 414.2; LCMS-ESI− (m/z): [M−H]− calcd for C23H23ClNO4: 412.1. Found: 412.0.