反应详情

To a 0° C. solution of 399 g (899 mmol) of (S)-2-((3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxopiperidin-1-yl)butanal (Example 151, Step B) in THF (9 L) was added 1.93 L (2.70 mol) of a 1.4 M solution of methylmagnesium bromide 75:25 in toluene/tetrahydrofuran slowly over a 30 min period so as to maintain an internal reaction temperature below 6° C. The yellow solution was warmed to room temperature and stirred for 1.5 h. At this time the reaction was cooled to 0° C. and quenched by cautious, slow addition of saturated aqueous ammonium chloride (4.6 L) so as to maintain an internal reaction temperature below 15° C. The mixture was warmed to room temperature, ethyl acetate was added, and the layers were separated. The aqueous layer was extracted with EtOAc (2×). The combined organic layers were washed with water (1×) and then saturated aqueous sodium chloride (1×), dried over Na2SO4, filtered and the filtrate was concentrated to afford a yellow oil. Purification of the residue by chromatography on silica (Biotage® Snap™ column; Biotage, LLC, Charlotte, N.C.), 5% acetone/5% EtOAc/90% hexanes grading to 5% acetone/29% EtOAc/66% hexanes) provided the title compound as a white solid.

1. temperatureto maintain an internal reaction temperature below 6° C
2. temperatureAt this time the reaction was cooled to 0° C.
3. customquenched by cautious,
4. additionslow addition of saturated aqueous ammonium chloride (4.6 L) so as
5. temperatureto maintain an internal reaction temperature below 15° C
6. temperatureThe mixture was warmed to room temperature
7. additionethyl acetate was added
8. customthe layers were separated
9. extractionThe aqueous layer was extracted with EtOAc (2×)
10. washThe combined organic layers were washed with water (1×)
11. dry with materialsaturated aqueous sodium chloride (1×), dried over Na2SO4
12. filtrationfiltered
13. concentrationthe filtrate was concentrated
14. customto afford a yellow oil
15. customPurification of the residue by chromatography on silica (Biotage® Snap™ column; Biotage, LLC, Charlotte, N.C.), 5% acetone/5% EtOAc/90% hexanes grading to 5% acetone/29% EtOAc/66% hexanes)