反应详情

To CH3CN (100 mL) was added 2,3-dihydro-3-benzo[b]furanethanol tosylate (1.50 g, 4.7 mmol), 1-(3-methoxy-2-pyridinyl)piperazine (0.91 g, 4.7 mmol), anhydrous K2CO3 (1.95 g, 14.1 mmol), KI (0.04 g, 0.24 mmol), and tetra-n-butylammonium hydrogen sulfate (0.08 g, 0.24 mmol). The mixture was heated at reflux under N2 atmosphere for 24 h. The reaction was concentrated in vacuo, several mL of H2O added and the reaction extracted with three portions of CH2Cl2. The combined organic extracts were washed with saturated aqueous NaCl solution, dried with anhydrous K2CO3, filtered, and concentrated in vacuo. Silica gel chromatography (EtOAc) of the concentrate afforded the free base which was treated with ethanolic HCl to yield the title compound (0.85 g, 39%, mp 100°-140° C.)

1. temperatureThe mixture was heated
2. temperatureat reflux under N2 atmosphere for 24 h
3. concentrationThe reaction was concentrated in vacuo, several mL of H2O
4. additionadded
5. extractionthe reaction extracted with three portions of CH2Cl2
6. washThe combined organic extracts were washed with saturated aqueous NaCl solution
7. dry with materialdried with anhydrous K2CO3
8. filtrationfiltered
9. concentrationconcentrated in vacuo
10. customSilica gel chromatography (EtOAc) of the concentrate afforded the free base which