反应详情

A mixture of 2,3-dihydrobenzo[b]furan-7-ylamine (6.8 g prepared in a similar manner to that described in Tetrahedron Letters 1982,23,147), 4-carbamoyl-1-(2,4-dinitrophenyl)pyridinium chloride (14.7 g prepared in a similar manner to that described in Example 2) and methanol (400 ml) was stirred under reflux for 5 hours then allowed to stand at ambient temperature and heated for 16 hours. The solvent was removed in vacuo, and the residue was triturated with hot acetone, cooled and filtered to give 1-(2,3-dihydrobenzo[b]furan-7-yl)-4-carbamoylpyridinium chloride as a yellow solid (11.5 g), m.p. 289°-290° C.

1. customprepared in a similar manner to that
2. customprepared in a similar manner to that
3. temperatureunder reflux for 5 hours
4. customto stand at ambient temperature
5. temperatureheated for 16 hours
6. customThe solvent was removed in vacuo
7. customthe residue was triturated with hot acetone
8. temperaturecooled
9. filtrationfiltered