反应详情

The title compound was prepared in a similar manner to Example 12 from LiAlH4 (760 mg, 20 mmol), (±)cis-1-[(4-phenoxy)phenoxy]-2-tert-butoxycarbonylaminoindane (1.39 mg, 3.3 mmol) and tetrahydrofuran (40 ml). After a reaction time of 3 h the reaction was worked up as previously described and subjected to column chromatography on silica gel eluting with 2% ethanol in chloroform to afford a pale pink oil (951 mg) which was converted to the HCl salt and crystallised to afford the title compound as a white solid. m.p. 188°-190° C. (from methanol-diethyl ether).

1. customAfter a reaction time of 3 h