反应详情

α-Bromoacetonitrile (0.209 mL, 3.00 mmol, 1.0 eq.) was dissolved in dry acetonitrile (30 mL) and treated with 2-methyl-3-benzyloxycarbonyl-5-hydroxyindole (0.972 g, 3.46 mmol, 1.2 eq.) and potassium carbonate (0.690 g, 5.0 mmol, 1.7 eq.). The reaction was heated to reflux and followed by TLC (hexane/ethyl acetate 3/2). After 6 hours, the reaction was quenched with water and extracted with ethyl acetate. The resulting organic layers were concentrated, taken up in methylene chloride, and filtered. The filtrate was evaporated to afford a brown solid: 0.490 g (51% yield).

1. temperatureThe reaction was heated
2. temperatureto reflux
3. customthe reaction was quenched with water
4. extractionextracted with ethyl acetate
5. concentrationThe resulting organic layers were concentrated
6. filtrationfiltered
7. customThe filtrate was evaporated
8. customto afford a brown solid