反应详情

4-[1-(Cyclohexylphenyl)-3-(3-methoxy-5-trifluoromethylphenyl)ureidomethyl]benzoic acid methyl ester (3.0 g) was dissolved in absolute ethanol (50 mL), sodium hydroxide (4 N, 15 mL) was added and the reaction mixture was stirred at room temperature for 16 hours. The organic solvent was removed in vacuo, and additional water (50 mL) was added, pH was adjusted with hydrochloric acid (4 N) to acidic reaction and then ethyl acetate (200 mL) was added. The organic phase was washed with water (5×50 mL), dried (magnesium sulphate), filtered and evaporated in vacuo. The residue was recrystallised from acetonitrile (25 mL) to afford 4-[1-(cyclohexylphenyl)-3-(3-methoxy-5-trifluoromethylphenyl)ureidomethyl]benzoic acid (1.83 g) as crystals.

1. customThe organic solvent was removed in vacuo, and additional water (50 mL)
2. additionwas added
3. custompH was adjusted with hydrochloric acid (4 N) to acidic reaction
4. washThe organic phase was washed with water (5×50 mL)
5. dry with materialdried (magnesium sulphate)
6. filtrationfiltered
7. customevaporated in vacuo
8. customThe residue was recrystallised from acetonitrile (25 mL)