反应详情

温度

25 °C

(R)-3-(4-[3-(3,5-Bis(trifluoromethyl)phenyl)-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino]-2-hydroxypropionic acid ethyl ester (0.26 g, 0.38 mmol) was dissolved in ethanol (96%, 15 mL) and added solution hydroxide (4 N, 0.57 mL, 2.3 mmol). After stirring at 25° C. for 1 hour the mixture was evaporated in vacuo, and the residue was added water (30 mL) and acidified with hydrochloric acid (4 N, 0.62 mL). The aqueous phase was extracted twice with ethyl acetate (25 mL and 10 mL) and the combined organic phases were washed with saturated sodium chloride:water (1:1), dried (magnesium sulphate) and concentrated in vacuo to afford 0.21 g of the title compound.

1. customwas evaporated in vacuo
2. additionthe residue was added water (30 mL)
3. extractionThe aqueous phase was extracted twice with ethyl acetate (25 mL and 10 mL)
4. washthe combined organic phases were washed with saturated sodium chloride:water (1:1)
5. dry with materialdried (magnesium sulphate)
6. concentrationconcentrated in vacuo