HRID968483

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15193022

未命名化合物

结构：CC(=O)NCC1CN(c2ccc3c(c2)CCNCC3)C(=O)O1

HCID69329130

未命名化合物

PRODUCTS

生成物

结构：CC(=O)NCC1CN(c2ccc3c(c2)CCN(c2nc4c(cc2F)c(=O)c(C(=O)O)cn4C2CC2)CC3)C(=O)O1

HCID69329556

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in a procedure analogous to that used in Example 6, using N-[2-Oxo-3-(2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)-oxazolidin-5-ylmethyl]-acetamide (0.25 g) and 1-Cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid (0.23 g). The product was triturated with EtOH to purify. MS (APCI) AP+, 550. NMR (DMSO6)1.1 (m, 2H), 1.22 (m, 2H), 1.74 (s, 3H), 3.04 (m, 4H), 3.3 (m, 6H), 3.70 (m, 2H), 4.0 (m, 2H), 4.65 (m, 1H), 7.13 (d, 1H), 7.26 (dd, 1H), 7.35 (d, 1H), 8.0 (d, 1H), 8.14 (t, 1H), 8.52 (s, 1H).

WORKUP

后处理

customThe product was triturated with EtOH
customto purify

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-238639d19bc744f8b2cc3f2d2675aa05
来源数据集: uspto-grants-2007_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07304050B2
来源说明: uspto-grants-2007_12

反应 SMILES

[O:1]=[C:2]1[N:6]([C:7]2[CH:17]=[CH:16][C:10]3[CH2:11][CH2:12][NH:13][CH2:14][CH2:15][C:9]=3[CH:8]=2)[CH2:5][CH:4]([CH2:18][NH:19][C:20](=[O:22])[CH3:21])[O:3]1.[CH:23]1([N:26]2[C:35]3[C:30](=[CH:31][C:32]([F:37])=[C:33](F)[N:34]=3)[C:29](=[O:38])[C:28]([C:39]([OH:41])=[O:40])=[CH:27]2)[CH2:25][CH2:24]1>>[C:20]([NH:19][CH2:18][CH:4]1[O:3][C:2](=[O:1])[N:6]([C:7]2[CH:17]=[CH:16][C:10]3[CH2:11][CH2:12][N:13]([C:33]4[N:34]=[C:35]5[C:30]([C:29](=[O:38])[C:28]([C:39]([OH:41])=[O:40])=[CH:27][N:26]5[CH:23]5[CH2:25][CH2:24]5)=[CH:31][C:32]=4[F:37])[CH2:14][CH2:15][C:9]=3[CH:8]=2)[CH2:5]1)(=[O:22])[CH3:21]