Indole → HCID 10707530, compound

HRID 969601Notes

Reaction equation

HRID 969601 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=[CH:13]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 798IndoleHCID 95884-Fluorobenzenesulfonyl chloride

Product 1

HCID 10707530HCID 10707530, compoundYield 81%

Procedure

The title compound was prepared from 4-fluoro-benzene sulfonyl chloride and 1H-indole, according to Method A, described above. Yield 81%; mp 135-137° C.; 1H NMR (CDCl3) δ 7.86-7.99 (m, 3H), 7.51-7.54 (m, 2H), 7.19-7.35 (m, 2H), 7.05-7.12 (m, 2H), 6.66-6.68 (dd, J=4 Hz, 1H); 13C NMR (CDCl3) δ 168.1, 164.0, 135.2, 134.7, 134.6, 131.2, 130.1, 129.9, 126.6, 125.2, 123.9, 121.9, 117.2, 116.9, 113.9, 110.0; MS (ES+) m/z 275.99 (M++1).

Sources & evidence

ORD record
ord-4b45c105a7054d5b9236adf9608c2022
Source dataset
uspto-grants-2007_12
Patent number
US07307099B2

Reaction notes

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