反应详情

8.1 g (28.1 mmol) of N-tert-butyl-2-methoxy-4-nitro-benzenesulfonamide is mixed with 350 ml of trifluoroacetic acid and stirred for 20 hours at room temperature. The trifluoroacetic acid is drawn off, and the remaining residue is then digested with ethyl acetate. 5.0 g (21.6 mmol, corresponding to 77% of theory) of the product is obtained. The ethyl acetate phase is concentrated by evaporation, and the residue that is obtained is purified by chromatography (DCM/EtOH 95:5, Flashmaster II). Another 0.84 g (3.6 mmol, corresponding to 13% of theory) of the product is obtained.

1. custom5.0 g (21.6 mmol, corresponding to 77% of theory) of the product is obtained
2. concentrationThe ethyl acetate phase is concentrated by evaporation
3. customthe residue that is obtained
4. customis purified by chromatography (DCM/EtOH 95:5, Flashmaster II)
5. customAnother 0.84 g (3.6 mmol, corresponding to 13% of theory) of the product is obtained