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HRID971435

反应详情

EQUATION

反应方程式

HRID 971435 的结构方程式

REACTANTS

反应物

4
结构：COC=O
HCID7865

Methyl formate

C2H4O2

结构：C[C@H]1C[C@H]2[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12
HCID236417

6alpha-Methyltestosterone

C20H30O2

结构：C[O-].[Na+]
HCID10942334

Methanol, sodium salt

CH3NaO

结构：CC1=C2CC[C@@H]3[C@H](CC[C@@]4(C)[C@H]3CC[C@]4(C)O)[C@@]2(C)CC(=CO)C1=O
HCID57349609

17-Hydroxy-2-(hydroxymethylidene)-4,17-dimethylandrost-4-en-3-one

C22H32O3

PRODUCTS

生成物

1
结构：C[C@H]1C[C@H]2[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC(=CO)C(=O)C=C12
HCID70603326

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CO
溶剂HCID887

Methanol

CH4O

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

17β-Hydroxy-2-hydroxymethylene-6α-methylandrost-4-en-3-one was prepared from 286 g. of 17β-hydroxy-6α-methylandrost-4-en-3-one (6α-methyltestosterone), 410 ml. of methyl formate, 140 g. of sodium methoxide, 40 ml. of methanol and 3 l. of tetrahydrofuran according to the procedure of Example 1, part (c). The total product, obtained nearly quantitative yield as an amber glass was used directly in the next reaction.

WORKUP

后处理

  1. customThe total product, obtained nearly quantitative yield as an amber glass
  2. customwas used directly in the next reaction