HRID973194

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)OC(CCCNS(C)(=O)=O)COc1ccc(F)cc1

HCID21401585

未命名化合物

结构：COC(=O)CCCC#CCN(C/C=C/C(COc1ccc(F)cc1)OC(C)=O)S(C)(=O)=O

HCID21401617

未命名化合物

HCID21401637

未命名化合物

PRODUCTS

生成物

$结构：CS(=O)(=O)N(C/C=C\CCCC(=O)O)C/C=C/C(O)COc1ccc(F)cc1$

HCID68120168

未命名化合物

PROCEDURE

实验过程

This compound is prepared by the procedure described in Example 2, Step I, except that the N-[4-acetoxy-5-(4-fluorophenoxy)pentyl]methanesulfonamide is replaced by an equimolar amount of N-[4-acetoxy-5-(4-fluorophenoxy)trans-2-pentenyl]methanesulfonamide (Example 6, Step G). This product is thus methyl 7-{N-[4-acetoxy-5-(4-fluorophenoxy)trans-2-pentenyl]methanesulfonamido}hept-5-ynoate. The subsequent hydrolysis is carried out as described in Example 2, Step J and affords 7-{N-[4-fluorophenoxy)trans-2-pentenyl]methanesulfonamido}hept-5-ynoic acid. The hydrogenation is carried out by the procedure described in Example 3 and affords the subject compound.

WORKUP

后处理

customThis compound is prepared by the procedure
customThe subsequent hydrolysis
customaffords 7-{N-[4-fluorophenoxy)trans-2-pentenyl]methanesulfonamido}hept-5-ynoic acid
customaffords the subject compound