反应详情

The synthesis of this compound is carried out as described in Example 1, except that, in Step B, the 1-chloro-4-acetoxynonane is replaced by an equimolar amount of 1-chloro-4-acetoxy-5,5-dimethylnonane (Example G, Step 3). The product of Step B is thus: di-tert.-butyl 2(4-acetoxy-5,5-dimethylnonyl)-2-(6-ethoxycarbonylhexyl)malonate. Subsequent steps yield: ethyl 8-carboxy-12-acetoxy-13,13-dimethylheptadecanoate (C); ethyl 8-chlorocarbonyl-12-acetoxy-13,13-dimethylheptadecanoate (D); ethyl carbamoyl-12-acetoxy-13,13-dimethylheptadecanoate (E); and 8-carbamoyl-12-hydroxy-13,13-dimethylheptadecanoic acid (F).

1. customThe synthesis of this compound