反应详情

The synthesis of this compound is carried out as described in Example 1 except that, in Step A, the ethyl 7-bromoheptanoate is replaced by an equimolar amount of methyl 3-methyl-7-iodoheptanoate. The product of Step A is thus: di-tert.-butyl (6-methoxycarbonyl-5-methylhexyl)malonate. Subsequent steps yield: di.-tert.-butyl 2-(4-acetoxynonyl)-2-(6-methoxycarbonyl-5-methylhexyl)malonate (D); methyl 8carboxy-12-acetoxy-3-methylheptadecanoate (V); methyl 8-chlorocarbonyl-12-acetoxy-3-methylheptadecanoate (D); methyl 8-carbamoyl-12-acetoxy-3-methylheptadecanote (E); and 8carbamoyl-12-acetoxy-3-methylheptadecanoic acid (F).

1. customThe synthesis of this compound