反应详情

3.01 g of 1-[2-acetoxy-1-(acetoxynethyl)ethoxy]- methyl-2-nitroimidazol (compound (1)) was dissolved in 50 ml of absolute methanol, and stirred at room temperature while being added with 5% absolute ethanol solution of sodium ethoxide dropwise until pH reached 9.0. Stirred at room temperature over 3 hours. Then Dowex 50 W (H+, made by Dow Chemical) was slowly added until the liquid had a pH of 7.0. Dowex 50 W was removed by suction filtration, and the solvent was distilled off under reduced pressure. The residue was subjected to recrystallization by ethanol to obtain 2.83 g of the title compound as light yellow needles (yield: 94%).

1. stirringStirred at room temperature over 3 hours
2. additionThen Dowex 50 W (H+, made by Dow Chemical) was slowly added until the liquid
3. customDowex 50 W was removed by suction filtration
4. distillationthe solvent was distilled off under reduced pressure
5. customThe residue was subjected to recrystallization by ethanol