HCID 19966945, compound → HCID 19967010, compound

HRID 976278Notes

Reaction equation

HRID 976278 reaction equation
[F:1][C:2]([F:27])([O:6][C:7]1[CH:8]=[C:9]([NH:13][C:14]2[N:19]=[C:18]([C:20]3[CH:25]=[CH:24][N:23]=[C:22](Cl)[CH:21]=3)[CH:17]=[CH:16][N:15]=2)[CH:10]=[CH:11][CH:12]=1)[CH:3]([F:5])[F:4]>NCCCO>[F:1][C:2]([F:27])([O:6][C:7]1[CH:8]=[C:9]([NH:13][C:14]2[N:19]=[C:18]([C:20]3[CH:25]=[CH:24][N:23]=[C:22]([NH:13][CH2:9][CH2:8][CH2:7][OH:6])[CH:21]=3)[CH:17]=[CH:16][N:15]=2)[CH:10]=[CH:11][CH:12]=1)[CH:3]([F:5])[F:4]

Participants

3

Reactant 1

HCID 19966945HCID 19966945, compound

Product 1

HCID 19967010HCID 19967010, compound

Reagents, catalysts & solvents 1

HCID 90863-Amino-1-propanolSolvent

Procedure

2 g (5.0 mmol)of N-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-4-(2-chloro-4-pyridyl)-2-pyrimidineamine are stirred for 44 h at 100° in 30 ml of 3-amino-1-propanol. After concentration by evaporation and chromatography (methylene chloride:methanol:conc. ammonia solution=95:5:1), N-[3-(1,1,2,2-tetrafluoro-ethoxy)-phenyl]-4-[2-(3-hydroxy-propyl-amino)-4-pyridyl]-2-pyrimidineamine is obtained; m.p. 141°-145°, MS(FAB): 438 (M+ +H), Rf =0.28 (methylene chloride:methanol:conc. ammonia solution=95:5:1).

Workup

  1. concentrationAfter concentration
  2. customby evaporation and chromatography (methylene chloride:methanol:conc. ammonia solution=95:5:1)

Sources & evidence

ORD record
ord-bb9e72ab79cb4591bbcdc3d84c35854c
Source dataset
uspto-grants-1997_03
Patent number
US05612340

Reaction notes

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