Ethyl Acetate → Tert-butyl 1-[3-(4-amidinophenyl)-2-oxo-5-oxazolidinylcarbonyl}piperid-4-yl-carboxylate

HRID 977212Notes

Reaction equation

HRID 977212 reaction equation
O=C1O[N:5]=[C:4]([C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH2:17][CH:16]([C:18]([N:20]4[CH2:25][CH2:24][CH:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22][CH2:21]4)=[O:19])[O:15][C:14]3=[O:33])=[CH:9][CH:8]=2)[NH:3]1.C(OCC)(=O)C>CO.[Ni]>[C:4]([C:7]1[CH:8]=[CH:9][C:10]([N:13]2[CH2:17][CH:16]([C:18]([N:20]3[CH2:21][CH2:22][CH:23]([C:26]([O:28][C:29]([CH3:31])([CH3:30])[CH3:32])=[O:27])[CH2:24][CH2:25]3)=[O:19])[O:15][C:14]2=[O:33])=[CH:11][CH:12]=1)(=[NH:3])[NH2:5]

Participants

5

Reactant 2

HCID 8857Ethyl AcetateHCID 136146332Tert-butyl 1-{3-[4-(5-oxo-1,2,4-oxadiazolin-3-yl)phenyl]-2-oxo-5-oxazolidinylcarbonyl}piperidine-4carboxylate

Product 1

HCID 15340942Tert-butyl 1-[3-(4-amidinophenyl)-2-oxo-5-oxazolidinylcarbonyl}piperid-4-yl-carboxylate

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

1.37 g of tert-butyl 1-{3-[4-(5-oxo-1,2,4-oxadiazolin-3-yl)phenyl]-2-oxo-5-oxazolidinylcarbonyl}piperidine-4-carboxylate are dissolved in 50 ml of methanol and hydrogenated over Raney nickel. The reaction mixture is, subsequently filtered and the filtrate is concentrated in vacuo. The product obtained is treated with 20 ml of ethyl acetate, with heating, and the product, after cooling, is filtered off with suction. Tert-butyl 1-[3-(4-amidinophenyl)-2-oxo-5-oxazolidinylcarbonyl}piperid-4-yl-carboxylate is obtained, m.p. 160°.

Workup

  1. filtrationsubsequently filtered
  2. concentrationthe filtrate is concentrated in vacuo
  3. customThe product obtained
  4. temperaturewith heating
  5. temperaturethe product, after cooling
  6. filtrationis filtered off with suction

Sources & evidence

ORD record
ord-897d8cdcf67d4e078c37df591e1c2bb4
Source dataset
uspto-grants-1997_03
Patent number
US05614535

Reaction notes

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