反应详情

12.0 g of the neutral sulphate of N-2-aminoethyl-4-morpholinecarboxamide and 2.16 g NaOH was refluxed in 100 ml of ethanol for 1 h. Thereafter 10 g of 3-(4-(2-cyclobutylmethoxyethoxy)phenoxy-1,2-epoxypropane in 50 ml of ethanol was added and the mixture refluxed for 20 h, filtered, and evaporated. The residue was dissolved in 175 ml of ethyl acetate and washed twice with water. Thereafter the title compound crystallized from the ethyl acetate phase. The crystals were filtered off and washed with ether. Yield 7.1 g. Melting point 91°-93° C. (base). The structure was determined using NMR-analysis.

1. temperaturethe mixture refluxed for 20 h
2. filtrationfiltered
3. customevaporated
4. dissolutionThe residue was dissolved in 175 ml of ethyl acetate
5. washwashed twice with water
6. customThereafter the title compound crystallized from the ethyl acetate phase
7. filtrationThe crystals were filtered off
8. washwashed with ether