反应详情

The experimental protocol used is the same as that described for compound 1, with N-[(4-aminophenyl) carbonylamino]-N′-[3,5-bis-(1,1-dimethylethyl)-4-hydroxy phenyl]-urea replacing the 3,5-bis-(1,1-dimethylethyl)-4-hydroxy-N-(4-aminophenyl)-benzamide. The free base is purified on a silica column (eluant: heptane/ethyl acetate: 1/1). The pure fractions are collected and concentrated under reduced pressure. The evaporation residue is diluted in 15 ml of acetone and salified with a molar solution of HCl in anhydrous ether, as described previously. 0.40 g (58%) of a yellow powder is obtained. Melting point: 254-255° C.

1. customThe free base is purified on a silica column (eluant: heptane/ethyl acetate: 1/1)
2. customThe pure fractions are collected
3. concentrationconcentrated under reduced pressure
4. additionThe evaporation residue is diluted in 15 ml of acetone