反应详情

Into 5 mL MeOH was dissolved 91 mg (0.195 mmol) 2-(4-tert-butylbenzoylamino)-N-(5-chloropyridin-2-yl)-5-methoxycarbonylbenzamide, followed by 0.47 mL of 0.5 N (0.23 mmol) NaOH. The mixture was stirred 16 h, evaporated, diluted with 39.0 mL water, and extracted with 15 mL EtOAc-15 mL hexane mixture. The aquous layer was acidified with dilute HCl and extracted with 30 mL EtOH. The organic layer was dried (MgSO4) and evaporated, giving 43 mg (.49%) title compound.

1. customevaporated
2. additiondiluted with 39.0 mL water
3. extractionextracted with 15 mL EtOAc-15 mL hexane mixture
4. extractionextracted with 30 mL EtOH
5. dry with materialThe organic layer was dried (MgSO4)
6. customevaporated