反应详情

温度

-15 °C

In a 50-mL r.b. flask, a solution of 3,4-dihydro-1,3,3-trimethylquinoxalin-2(1H)-one (830 mg, 4.36 mmol) in 20 mL of conc. H2SO4 was cooled to −15° C. A solution of HNO3 (336 mg, 4.80 mmnol, 1.1 equiv) dissolved in conc. H2SO4 (1 mL) was then added dropwise via syringe in order to maintain a temperature below −5° C. After complete addition the reaction was allowed to stir at −15° C. for 15 min, warmed to rt, poured over NaOH (15 g) pellets and ice. After complete solution of the NaOH pellets, the red precipitate was filtered, redissolved in EtOAc (150 mL), washed with H2O (20 mL), brine (20 mL), dried (MgSO4), filtered, and concentrated to give a orange solid. No further purification is required to obtain 960 mg (94%) of 3,4-dihydro-1,3,3-trimethyl-6-nitroquinoxalin-2(1H)-one as an orange solid. Data for 3,4-dihydro-1,3,3-trimethyl-6-nitroquinoxalin-2 (1H)-one: 1H NMR (400 MHz, CDCl3) δ 7.76 (dd, J=8.8, 2.5, 1H), 7.55 (d, J=2.4, 1H), 6.96 (d, J=8.9, 1H), 4.04 (bs, 1H), 3.42 (s, 3H), 1.41 (s, 6H).

1. additionwas then added dropwise via syringe in order
2. temperatureto maintain a temperature below −5° C
3. additionAfter complete addition the reaction
4. temperaturewarmed to rt
5. filtrationAfter complete solution of the NaOH pellets, the red precipitate was filtered
6. dissolutionredissolved in EtOAc (150 mL)
7. washwashed with H2O (20 mL), brine (20 mL)
8. dry with materialdried (MgSO4)
9. filtrationfiltered
10. concentrationconcentrated
11. customto give a orange solid
12. customNo further purification