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HRID991666

反应详情

EQUATION

反应方程式

HRID 991666 的结构方程式

REACTANTS

反应物

2
结构：OCCOc1cccnc1
HCID21908997

2-[(Pyridin-3-yl)oxy]ethan-1-ol

C7H9NO2

结构：C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1nccnc1Cl
HCID86591091

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H]1CNCCN1c1nccnc1OCCOc1cccnc1.Cl
HCID131723551

未命名化合物

PROCEDURE

实验过程

The title compound was prepared starting from 2-(3-pyridyloxy)ethanol (from Example 150, Step 1) and 3-chloro-2-[4-tert-butoxycarbonyl-(2R)-methyl-1-piperazinyl]pyrazine (from Example 172, Step 2). The pure free base was precipitated as its hydrochloride salt with HCl/ether to give the title compound as white crystals: yield 31%; mp 180-183° C.; HRMS m/z calcd for C16H21N5O2 (M)+ 315.1695, found 315.1689. Anal. (C16H21N5O2.1.33HCl) C, H, N.

WORKUP

后处理

  1. customThe title compound was prepared
  2. customThe pure free base was precipitated as its hydrochloride salt with HCl/ether