反应详情

4 g of ethyl [3,5-bis(5-chloro-2-hydroxyphenyl)-[1,2,4]triazol-1-yl]acetate (Example 40) and 2.6 g of 4-(2-aminoethyl)morpholine are boiled under reflux for 18 h in 50 ml of ethanol. The mixture is cooled, poured onto water and extracted with ethyl acetate. The combined organic phases are dried over sodium sulfate and concentrated on a rotary evaporator. The residue is crystallized from isopropanol. After drying, 2-[3,5-bis(5-chloro-2-hydroxyphenyl)-[1,2,4]triazol-1-yl]-N-(2-morpholin-4-yl-ethyl)acetamide remains as colorless crystals of m.p. 224-226° C.

1. temperatureThe mixture is cooled
2. additionpoured onto water
3. extractionextracted with ethyl acetate
4. dry with materialThe combined organic phases are dried over sodium sulfate
5. concentrationconcentrated on a rotary evaporator
6. customThe residue is crystallized from isopropanol
7. customAfter drying