N-羟基邻苯二甲酰亚胺

N-Hydroxyphthalimide

HCID 10665CAS 524-38-9
子结构检索查找相似结构

基本信息

标准SMILES
O=C1c2ccccc2C(=O)N1O
InChIKey
CFMZSMGAMPBRBE-UHFFFAOYSA-N
分子式
C8H5NO3
平均分子量
163.13 g/mol
单同位素质量
163.02694302

概述

causes contact dermititis

名称与标识

首选名称
N-Hydroxyphthalimide
IUPAC
2-hydroxyisoindole-1,3-dione
中文名
N-羟基邻苯二甲酰亚胺
英文名
N-Hydroxyphthalimide
分子式
C8H5NO3
分子量
163.13

名称与别名

N-HYDROXYPHTHALIMIDE524-38-92-Hydroxyphthalimide1H-Isoindole-1,3(2H)-dione, 2-hydroxy-Phthalimide, N-hydroxy-BXI99M81X0NSC-770F 802DTXSID7060170RefChem:830142DTXCID1041188208-358-1
展开更多名称
羟基萘羟基酞亚胺N-羟基酞亚胺N-羟基酞酰亚胺屈西多巴杂质18N-羟基邻苯二甲酰利伐沙班杂质141N-羟基邻苯二甲亚胺N-羟基邻苯二甲酰亚N-羟基苯邻二甲酰亚胺nhpihydroxyphthalimideHOPHTN-Hydrophthalimide
2-hydroxyisoindoline-1,3-dione2-Hydroxy-1H-isoindole-1,3(2H)-dione2-hydroxyisoindole-1,3-dioneMFCD000058912-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione2-oxidanylisoindole-1,3-dioneCHEMBL2760572-hydroxy-isoindole-1,3-dione

数据库标识

CAS
524-38-9
PubChem CID
10665
DTXSID
DTXSID7060170
ChEMBL
CHEMBL276057
UNII
BXI99M81X0
EC Number
208-358-1
Nikkaji
J26.847J

性质

结构计算性质

XLogP
0.8
极性表面积
57.6 Ų
氢键供体
1
氢键受体
3
可旋转键
0
重原子
12

实验与物化性质

Chemical ClassesNitrogen Compounds -> Other Nitrogen Rings
SpringerMaterials PropertiesNuclear quadrupole resonance spectroscopy
Physical DescriptionYellowish or colorless solid; [Merck Index] White or off-white crystalline powder; [Alfa Aesar MSDS]
Ionization Efficiency · 6 条

Negative

-0.43

10.5

Agilent XCT

Electrospray ionization

ammonia (10nM)

物理化学性质

熔点
233 °C · 233 °C (dec.) (lit.)
沸点
290.19 °C · 290.19°C (rough estimate)
密度
1.64 g/cm3 · 1.64 g/cm3
蒸气压
0 Pa · 0Pa at 25℃
折射率
1.551 · 1.5510 (estimate)
储存条件
Keep in dark place,Sealed in dry,Room Temperature

安全与法规

GHS分类

GHS Classification · 4 条

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 152 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危害信息

Regulatory Information · 3 条

Chemical: 1H-Isoindole-1,3(2H)-dione, 2-hydroxy-

Status: Cease Manufacture Update: 24-03-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/19261

1H-Isoindole-1,3(2H)-dione, 2-hydroxy-: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryIntravenous LD50 (mouse) = 178 mg/kg; [RTECS] Causes contact dermatitis. [ChemIDplus] A skin and strong eye irritant; [Alfa Aesar MSDS] See N-Aminophthalimide.
Hazard Classes and CategoriesSkin Irrit. 2 (100%)

毒理信息

Adverse EffectsSkin Sensitizer - An agent that can induce an allergic reaction in the skin.

安全数据

wgk
3
tsca
TSCA listed
RTECS号
TI5200000
危险等级
IRRITANT
存储类别
11 - Combustible Solids
安全说明
26-36-37/39

化学与工业

用途与制造

UsesUsed as a catalyst for oxidation reactions; [Merck Index]
General Manufacturing Information1H-Isoindole-1,3(2H)-dione, 2-hydroxy-: ACTIVE

应用领域

用途用作阿米卡星等药物中间体，也用作烷基氧化剂、催化剂、选矿捕收剂

用途制备胺核苷，以用于偶联反应生成非阴离子反义寡聚核苷

上下游产品信息

试剂价格

A13862 · 100g
N-羟基邻苯二甲酰亚胺, 98+% N-Hydroxyphthalimide, 98+% — 297元
32987 · 500g
N-羟基邻苯二甲酰亚胺N-Hydroxyphthalimide, 98%, Thermo Scientific Chemicals — 1128元

供应商50 家

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

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