2-二环己基膦-2',4',6'-三异丙基联苯

2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl

HCID 11155794CAS 564483-18-7

基本信息

标准SMILES
CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1
InChIKey
UGOMMVLRQDMAQQ-UHFFFAOYSA-N
分子式
C33H49P
平均分子量
476.7 g/mol
单同位素质量
476.35718856

名称与标识

首选名称
2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl
IUPAC
dicyclohexyl-[2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane
中文名
2-二环己基膦-2',4',6'-三异丙基联苯
英文名
X-PHOS
分子式
C33H49P
分子量
476.72

名称与别名

564483-18-7X-PhosXphos phosphine ligand [MI]2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylR271FU23T8(2',4',6'-triisopropyl-1,1'-biphenyl-2-yl)dicyclohexylphosphineBuchwald phosphine ligands, xphos phosphine ligand-DTXSID504571262-(DICYCLOHEXYLPHOSPHINO)-2',4',6'-TRI(ISOPROPYL)BIPHENYLPhosphine, dicyclohexyl(2',4',6'-tris(1-methylethyl)(1,1'-biphenyl)-2-yl)-PHOSPHINE, DICYCLOHEXYL[2',4',6'-TRIS(1-METHYLETHYL)[1,1'-BIPHENYL]-2-YL]-RefChem:471294
展开更多名称
-三异丙基联苯阿贝西利杂质31阿贝西利杂质392-二环己基膦-2,4,62-二环己基磷-2'2-二环己基磷-2,4,6-三异丙2-环己基-2,4,6-三异丙基联苯X-PHOS,CHEMDOSE? 片2-环己基膦-1,3,5-三异丙基联苯CHEMDOSE?,X-PHOS 浸渍片dicyclohexyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphane2-(Dicyclohexylphosphanyl)-2',4',6'-tris(isopropyl)biphenyl5-BROMO-4-CHLORO-3-INDOLYL PHOSPHATE2-Dicyclohexylphosphino-22-Dicyclohexylphosphino-2,4,6-triisopropylbiphenylDicyclohexyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphineX-PH0Sdicyclohexyl-[2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane
XPHOS PHOSPHINE LIGANDDTXCID10407945XPhos2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenylMFCD04117682dicyclohexyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphine

数据库标识

CAS
564483-18-7
PubChem CID
11155794
DTXSID
DTXSID50457126
UNII
R271FU23T8
EC Number
611-387-6
Nikkaji
J1.911.682D、J3.650.095F

性质

结构计算性质

XLogP
10.1
极性表面积
0 Ų
氢键供体
0
氢键受体
0
可旋转键
7
重原子
34

物理化学性质

熔点
187 · 187-190 °C(lit.)
沸点
569.8 · 569.8±50.0 °C(Predicted)
储存条件
Inert atmosphere,Room Temperature
溶解度
Benzene (Slightly)
形态
Powder
颜色
white

安全与法规

GHS分类

GHS Classification · 6 条

This chemical does not meet GHS hazard criteria for 35.2% (38 of 108) of reports.

Warning

H302+H312+H332 (21.3%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation];H302 (26.9%): Harmful if swallowed [Warning Acute toxicity, oral];H312 (21.3%): Harmful in contact with skin [Warning Acute toxicity, dermal];H315 (59.3%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (59.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H332 (21.3%): Harmful if inhaled [Warning Acute toxicity, inhalation];H335 (58.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H413 (25.9%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]

P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 108 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 38 of 108 reports by companies.;There are 13 notifications provided by 70 of 108 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危害信息

Hazard Classes and CategoriesAcute Tox. 4 (26.9%);Acute Tox. 4 (21.3%);Skin Irrit. 2 (59.3%);Eye Irrit. 2 (59.3%);Acute Tox. 4 (21.3%);STOT SE 3 (58.3%);Aquatic Chronic 4 (25.9%)

安全数据

wgk
3
tsca
No
存储类别
13 - Non Combustible Solids
安全说明
37/39-26-36/37
海关编码
29319090
危险品标志
Xn

化学与工业

应用领域 · 4 条

简介2-二环己基膦-2',4',6'-三异丙基联苯是一种单膦配体,它可与多种过渡金属发生配位,在化学合成领域中常用于钯催化Suzuki偶联反应,迈克尔加成反应等,在基础化学研究领域中有广泛的应用。

用途2-二环己基膦-2',4',6'-三异丙基联苯(XPHOS)用作合成新型[1,2,4]三唑并[4,3-a]吡嗪衍生物的再生剂,作为潜在的选择性c-met抑制剂,具有更好的药代动力学特性。

用途偶联反应中,催化体系中配体成份

用途用作钯催化Suzuki偶联反应的配体,生成文朵灵的C-15类似物;用于钯催化2-卤代苯胺直接环化生成吲哚和色氨酸;区域规则性聚噻吩的合成。用于深入研究芳烃磺酸酯、芳基卤的钯催化胺化和酰胺化反应的配体

试剂价格

D5038 · 1g
2-二环己基膦-2',4',6'-三异丙基联苯2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl — 640元
D5038 · 5g
2-二环己基膦-2',4',6'-三异丙基联苯2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl — 1990元

供应商50 家

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]
韶远科技(上海)有限公司021-50795510 4000665055 · [email protected]

相关反应

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