2-甲基-6-硝基苯胺

2-Methyl-6-nitroaniline

HCID 11298CAS 570-24-1

基本信息

标准SMILES
Cc1cccc([N+](=O)[O-])c1N
InChIKey
FCMRHMPITHLLLA-UHFFFAOYSA-N
分子式
C7H8N2O2
平均分子量
152.15 g/mol
单同位素质量
152.0585775

概述

2-methyl-6-nitroaniline appears as orange-yellow prisms or brown granular powder. (NTP, 1992)

名称与标识

首选名称
2-Methyl-6-nitroaniline
IUPAC
2-methyl-6-nitroaniline
中文名
2-甲基-6-硝基苯胺
英文名
2-Methyl-6-nitroaniline
分子式
C7H8N2O2
分子量
152.15

名称与别名

2-METHYL-6-NITROANILINE570-24-12-Amino-3-nitrotoluene6-Nitro-o-toluidineBenzenamine, 2-methyl-6-nitro-6-Methyl-2-nitroaniline1-Amino-2-methyl-6-nitrobenzene3-Nitro-2-aminotolueneo-Toluidine, 6-nitro-2-nitro-6-methylanilineNSC 286OUP165YKBC
展开更多名称
6-硝基邻甲苯胺2-甲基-6-硝基苯6-硝基-O-甲苯胺2-氨基-3-硝基甲苯6-硝基-2-甲基苯胺2-甲基-6-硝基苯胺2-甲基-6-硝基苯按2-氨基-3-甲基硝基苯2-甲基-6-硝基苯胺,98%2-氨基-3-硝基甲苯 标准品2-Amino-3-nitro touleneNSC 52218-6-nitroaniL6-Nitro-o-tolLABOTEST-BB LTBB0006216-Nitro-2-Methylaniline
EINECS 209-329-62-Methyl-6-nitro-benzenamineIMEXINE FPNSC-286NSC-522182-amino-3-methylnitrobenzeneDTXSID7025631FCMRHMPITHLLLA-UHFFFAOYSA-

数据库标识

CAS
570-24-1、60999-18-0
PubChem CID
11298
DTXSID
DTXSID7025631
UNII
OUP165YKBC
EC Number
209-329-6
Nikkaji
J28.416E

性质

结构计算性质

XLogP
2
极性表面积
71.8 Ų
氢键供体
1
氢键受体
3
可旋转键
0
重原子
11

实验与物化性质

Chemical ClassesNitrogen Compounds -> Nitroanilines
CosmeticsHair dyeing
SpringerMaterials PropertiesSurface tension
Density1.19 at 212 °F (NTP, 1992) - Denser than water; will sink
Solubilityless than 1 mg/mL at 73 °F (NTP, 1992)
Melting Point199 to 205 °F (NTP, 1992)

物理化学性质

熔点
93 · 93-96 °C (lit.)
沸点
124 °C · 124 °C / 1mmHg
密度
1.19 g/cm3 · 1.19 g/cm3
折射率
1.6276 · 1.6276 (estimate)
闪点
110 °C · 110 °C
储存条件
Keep in dark place,Inert atmosphere,Room temperature

化学性质

橙色或黄色棱柱状结晶。熔点97℃。溶于醇、醚、苯和氯仿,微溶于水。

安全与法规

GHS分类

GHS Classification · 6 条

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P260, P261, P262, P264, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P316, P319, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 47 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

危害信息

Regulatory Information · 3 条

Chemical: Benzenamine, 2-methyl-6-nitro-

Status: No longer Valid Update: 25-04-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/24595

6-Nitro-o-toluidine: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Benzenamine, 2-methyl-6-nitro-: Human health tier II assessment
DOT LabelPoison
Fire HazardsFlash point data for this compound are not available, but it is probably combustible. (NTP, 1992)
Health HazardsExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
Hazards Summary · 1 条

A mild skin and eye irritant in rabbits at 3% concentration in 1,2-propanediol; No evidence of skin sensitization in guinea pigs; Hepatotoxicity observed in 28-day oral studies of rats; No evidence of embryotoxicity or teratogenicity in rats; [EC: SCCNFP] May cause irritation; May induce methemoglobinemia; Toxic by ingestion, inhalation, and skin absorption; Targets the blood; [Sigma-Aldrich MSDS] See 2-Nitroaniline.

安全与防护

Fire FightingFires involving this material can be controlled using a carbon dioxide, dry chemical or Halon extinguisher. (NTP, 1992)
First Aid · 1 条

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 条

SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
Personal Protective Equipment (PPE) · 1 条

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

毒理信息

Adverse EffectsOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

安全数据

F
10
wgk
3
hazard_note
Toxic
包装类别
Ⅲ
危险等级
IRRITANT
存储类别
6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects

化学与工业

用途与制造

Uses · 2 条

Used in semi-permanent hair dyes; [EC: SCCNFP]

Dressing Hair [Category: Other]

Use ClassificationCosmetics -> Hair dyeing

应用领域

用途2-甲基-6-硝基苯胺是一种用于有机合成的化合物。染料和代谢物,环境测试。

制备方法

生产方法邻甲基乙酰苯胺用70%硝酸硝化得到的硝基邻甲基乙酰苯胺,与浓盐酸一起加热至沸,反应产物进行水蒸气蒸馏,得到6-硝基邻甲苯胺,收率约50%。

试剂价格

XW010363 · 50G
2-甲基-6-硝基苯胺2-methyl-6-nitroaniline;6-nitro-o-toluidine;2-amino-3-nitrotoluene — 98元
N0467 · 25G
2-甲基-6-硝基苯胺2-Methyl-6-nitroaniline — 675元

供应商50 家

国药集团化学试剂有限公司86-21-63210123 · [email protected]
格林斯柏生物科技(江苏)有限公司0523-87726088 13705266400 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

相关反应

66 条

关联笔记

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