9-芴甲基-N-琥珀酰亚胺基碳酸酯

N-(9-Fluorenylmethoxycarbonyloxy)succinimide

HCID 134122CAS 82911-69-1

子结构检索查找相似结构

基本信息

标准SMILES: O=C(OCC1c2ccccc2-c2ccccc21)ON1C(=O)CCC1=O
InChIKey: WMSUFWLPZLCIHP-UHFFFAOYSA-N
分子式: C19H15NO5
平均分子量: 337.3 g/mol
单同位素质量: 337.09502258

概述

used in the preparation of Fmoc-amino acids

名称与标识

首选名称: N-(9-Fluorenylmethoxycarbonyloxy)succinimide
IUPAC: (2,5-dioxopyrrolidin-1-yl) 9H-fluoren-9-ylmethyl carbonate
中文名: 9-芴甲基-N-琥珀酰亚胺基碳酸酯
英文名: Fmoc-OSu
分子式: C19H15NO5
分子量: 337.33

名称与别名

82911-69-1N-(9-Fluorenylmethoxycarbonyloxy)succinimideFmoc-onsu9-Fluorenylmethylsuccinimidyl carbonateAD7AUS3GKTDTXSID902320902,5-PYRROLIDINEDIONE, 1-[[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]OXY]-2,5-Pyrrolidinedione, 1-(((9H-fluoren-9-ylmethoxy)carbonyl)oxy)-RefChem:926928DTXCID90154581433-520-5Fmoc-OSu

展开更多名称

9-芴甲氧羰基碳酸酯芴甲氧羰酰琥珀酰亚胺芴甲氧羰酰唬珀酰亚胺Fmoc-琥珀酰亚胺芴甲氧羧酰琥珀酰亚胺FMOC-OSU(冷库)9-芴甲氧羰酰琥珀酰亚胺化合物 Fmoc-OSu9-芴基甲氧羰基丁二酰亚胺9-芴甲基-N-琥珀...Fomc-OsuFMOC-SU2,5-dioxopyrrolidin-1-yl 9H-fluoren-9-ylMethyl carbonateFMOC-Succinimide

Fmoc N-hydroxysuccinimide ester9-Fluorenylmethyl succinimidyl carbonate(9H-fluoren-9-yl)methyl (2,5-dioxopyrrolidin-1-yl) carbonate(2,5-dioxopyrrolidin-1-yl) 9H-fluoren-9-ylmethyl carbonate9-Fluorenylmethyl N-succinimidyl carbonateN-(9-Fluorenylmethoxycarbonyloxy) succinimideMFCD00010733C19H15NO5

数据库标识

CAS: 82911-69-1
PubChem CID: 134122
DTXSID: DTXSID90232090
UNII: AD7AUS3GKT
EC Number: 433-520-5、617-400-1
Nikkaji: J208.522D

性质

结构计算性质

XLogP: 2.7
极性表面积: 72.9 Å²
氢键供体: 0
氢键受体: 5
可旋转键: 5
重原子: 25
形式电荷: 0
复杂度: 524

物理化学性质

熔点: 150 · 150-153 °C(lit.)
沸点: 150 · 150-153°C
密度: 1.346 · 1.3460 (rough estimate)
折射率: 1.5 · 1.5000 (estimate)
储存条件: 2 · 2-8°C
溶解度: Soluble in dimethyl sulfoxide and dimethyl formamide.
形态: Microfine Powder
颜色: White or almost white
敏感性: Moisture Sensitive
BRN: 3569540 · 3569540
稳定性: Moisture Sensitive
主要应用: peptide synthesis
InChI: InChI=1S/C19H15NO5/c21-17-9-10-18(22)20(17)25-19(23)24-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2
InChIKey: WMSUFWLPZLCIHP-UHFFFAOYSA-N
SMILES: C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)ON1C(=O)CCC1=O
CAS 数据库: 82911 · 82911-69-1(CAS DataBase Reference)

安全与法规

GHS分类

GHS Classification · 6 条

Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P270, P272, P273, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement)

Warning

H302 (98.8%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P270, P272, P273, P280, P301+P317, P302+P352, P321, P330, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement)

危害信息

Regulatory Information · 2 条

Status: Active Update: 29-11-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13924

2,5-Pyrrolidinedione, 1-(9H-fluoren-9-ylmethoxy)carbonyloxy-: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and Categories · 4 条

Acute Tox. 4 (100%)

Acute Tox. 4 (98.8%)

Acute toxicity - category 4

Acute Tox. 4 *

安全数据

F: 10-21
wgk: 3
hazard_note: Moisture Sensitive
危险等级: 9
存储类别: 11 - Combustible Solids
安全说明: 22-24/25-26/37/39-26-61-37-24
海关编码: 29251995
危险品标志: Xi,N,Xn
危险性类别: Acute Tox. 4 OralAquatic Chronic 2Skin Sens. 1
危险类别码: 36/37/38-51/53-43-22
危险品运输编号: UN 3077 9 / PGIII

化学与工业

应用领域 · 4 条

用途医药中间体。

用途氨基酸衍生试剂，荧光检测，试剂较稳定，无二肽和三肽杂质且反应速度更快。

用途非常高效的选择性试剂，用于羟基氨基酸衍生物N-(9-氟乙基甲氧基羰基)的制备；用于糖肽类合成

用途9-芴甲基-N-琥珀酰亚胺基碳酸酯可用作氨基酸保护剂。

上下游产品信息

下游产品

试剂价格

HY-79647 · 25 g: 9-芴甲基-N-琥珀酰亚胺基碳酸酯Fmoc-OSu — 100元
HY-79647 · 100 g: 9-芴甲基-N-琥珀酰亚胺基碳酸酯Fmoc-OSu — 160元

供应商50 家

国药集团化学试剂有限公司86-21-63210123 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

成都市久鼎化学技术有限公司18584079237 · [email protected]

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