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乙酸汞
醋酸G · 醋酸汞 · 乙酸汞 · 乙酸高汞 · 二乙酸汞 · YSG汞 · 醋酸汞试剂 · 二乙酰基氧基汞
标识与物理属性
| CAS No. | 1600-27-7 |
|---|---|
| 分子式 | Hg(CH3COO)2 |
| 平均分子量 | 318.68 g/mol |
| 单同位素质量 | 319.99725167 g/mol |
| SMILES | CC(=O)[O-].CC(=O)[O-].[Hg+2] |
| InChIKey | BRMYZIKAHFEUFJ-UHFFFAOYSA-L |
| PubChem CID | 15337 |
| EC No. | 209-766-2 |
| DTXSID | DTXSID4042123 |
| 中文名 | 乙酸汞 |
化学与物理性质
| 极性表面积 | 80.3 |
|---|---|
| 氢键供体 | 0 |
| 氢键受体 | 4 |
| 可旋转键 | 0 |
| 重原子 | 9 |
| 形式电荷 | 0 |
| 复杂度 | 25.5 |
| 物质类别 | Metals -> Mercury Compounds, Inorganic |
| 气味 | Mild vinegar-like odorSlight acetic odorSlight acetic acid odor |
| 密度 | 3.27 (EPA, 1998) - Denser than waterwill sink3.283.28 g/cm³3.28 @25 °C3,29 g/cm3 |
| Color/Form | White-yellow crystals or powderFine white powder or colorless shiny crystal flakesSolid at 15 °C and 1 atm |
| 溶解性 | Soluble in diethyl ether and ethanolOne g dissolves in 2.5 ml cold, 1 ml boiling watersol in alcohol.In water, 2.50X10+5 mg/l @ 10 °C100 G/100 ML WATER AT 100 °CSolubility in water, g/100ml at 20 °C: 40 (good)Water (Slightly)Soluble in water. |
| 沸点 | Decomposes (EPA, 1998) |
| Decomposition | 178 °C |
| 熔点 | 352 to 356 °F (EPA, 1998)179 °C (decomposes)179-182 °C(lit.) |
| 蒸气压 | 0.17 [mmHg]Vapor pressure, Pa at 25 °C: 0.24 (calculated) |
| Physical Description | Mercury acetate is a white crystalline solid with an odor of vinegar. Sensitive to light. Density 3.25 g / cm3. Toxic by inhalation (dust, etc.) and by ingestion.Water soluble white crystals with vinegar odor[CAMEO]WHITE CRYSTALS OR WHITE CRYSTALLINE POWDER. |
| Stability/Shelf Life | SENSITIVE TO LIGHTAQ SOLN DECOMP ON STANDING, YIELDING A YELLOW PRECIPITATE |
| Other Experimental Properties | Aqueous solutions decompose on standing, yielding /unidentified/ yellow precipitate. |
| 堆积密度 | 1000kg/m3 |
| 蒸气密度 | 11 (vs air) |
| 储存条件 | Store at RT. |
| 形态 | Solid |
| 比重 | 3.27 |
| 颜色 | White to almost white |
| 敏感性 | Light Sensitive |
| 水解敏感性 | 0: forms stable aqueous solutions |
| Merck | 14,5873 |
| BRN | 3563831 |
| 稳定性 | Stable. Incompatible with strong oxidizing agents, strong bases. May decompose upon exposure to light. |
| InChI | 1S/2C2H4O2.Hg/c2*1-2(3)4/h2*1H3,(H,3,4)/q+2/p-2 |
| InChIKey | BRMYZIKAHFEUFJ-UHFFFAOYSA-L |
| SMILES | CC(=O)O[Hg]OC(C)=O |
| CAS 数据库 | 1600-27-7(CAS DataBase Reference) |
| EPA化学物质信息 | Mercuric acetate (1600-27-7) |
化学性质
白色结晶或结晶粉末。熔点179-182℃（过热分解）；相对密度3.28。溶于乙醇和水。水溶液放置后分解产生黄色沉淀，对光有敏感性。有乙酸气味。
安全与法规
| GHS 分类 | DangerH300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]P260, P262, P264, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P319, P320, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 71 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H300: Fatal if swallowed [Danger Acute toxicity, oral] |
|---|---|
| 法规信息 | Chemical: Acetic acid, mercury(2+) saltMercury (II) acetate: HSNO Approval: HSR004543 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| 运输标签（DOT） | Poison |
| 火灾危害 | When heated to decomposition, it emits toxic fumes of mercury. Avoid light. (EPA, 1998)· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| 火灾可能性 | Not flammable |
| 健康危害 | It may cause death by hypovolemic shock or kidney failure. Chronic exposure may lead to kidney failure. (EPA, 1998)· Highly toxic, may be fatal if inhaled, ingested or absorbed through skin. |
| 危害概述 | Corrosive to the skin, eyes, and respiratory tractMay have effects on the kidneys, CNS, and peripheral nervous systemMay cause skin sensitization[ICSC] See Mercury, inorganic compounds and the linked occupational disease. |
| 运输编号与指南（DOT） | 1629 151 |
| 反应性基团 | Salts, Basic |
| 欧共体分类 | Symbol: T+, NR: 26/27/28-33-50/53S: (1/2)-13-28-36-45-60-61Note: A, 1 |
| 联合国分类 | UN Hazard Class: 6.1UN Pack Group: II |
| RCRA 要求 | D009A solid waste containing mercury may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Mercury/ |
| OSHA Standards | Permissible Exposure Limit: Table Z-2 8-hr Time Weighted Avg: 0.01 mg/cu m. /Organo alkyl mercury/Permissible Exposure Limit: Table Z-2 Acceptable Ceiling Concentration: 0.04 mg/cu m. /Organo alkyl mercury/Vacated 1989 OSHA PEL TWA 0.01 mg/cu mSTEL 0.03 mg/cu m, skin designation, is still enforced in some states. /Mercury (organo) alkyl compounds, as Hg/ |
| 消防 | Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. Wear boots, protective gloves, and goggles. Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. Wear self-contained breathing apparatus when fighting fires involving this material. If contact with the material is anticipated, wear full protective clothing.In case of fire in the surroundings, use appropriate extinguishing media. |
| 急救措施 | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention . |
| 泄漏应急措施 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. |
| 急救 | Warning: Effects may be delayed. Caution is advised.General First Aid: |
| 安全储存 | Separated from food and feedstuffs. Keep in the dark. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. Well closed. |
| 暴露控制与个人防护 | · Wear positive pressure self-contained breathing apparatus (SCBA).0.02 [mg/m3], as Hg, inhalable fraction[German Research Foundation (DFG)] |
| 灭火程序 | If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical, or carbon dioxide. |
| 储存条件 | KEEP WELL CLOSED AND PROTECTED FROM LIGHTStore at ambient temperature |
| 非火灾泄漏应对 | Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]: |
| 处置方法 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| 泄漏处置 | Consult an expert! Personal protection: chemical protection suit. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations. |
| Preventive Measures | If material not involved in fire: Keep material out of water sources and sewers.Personnel protection: Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. ... Wash away any material which may have contacted the body with copious amounts of water or soap and water. ... If contact with the material anticipated, wear appropriate chemical protective clothing. |
| Treatment | Mercury poisoning is treated by immediate decontamination and chelation therapy using DMSA, DMPS, DPCN, or dimercaprol. (A7) |
| 相互作用 | EMBRYONIC EFFECTS OF COMBINATIONS OF MERCURIC ACETATE (2 OR 4 MG/KG) & CADMIUM SULFATE (2 MG/KG) ADMIN TO PREGNANT HAMSTERS ON 8TH DAY OF GESTATION WERE MUCH MORE SEVERE THAN THOSE OF MERCURIC ACETATE COMBINATIONS WITH ZINC SULFATE (2 MG/KG). THE PROTECTIVE VALUE OF ZINC SULFATE AGAINST THE EMBRYOPATHIC EFFECTS OF MERCURIC ACETATE WAS ALSO DETECTED BY THE MANNER OF ADMIN OF THE 2 METALS. THE MERCURIC ACETATE/ZINC SULFATE CONBINATIONS PRODUCED ONLY A FEW MALFORMATIONS.(14)C-LABELED N-ETHYLMALEIMIDE INCUBATED WITH RABBIT OR HUMAN SERUM CAN COMPETE WITH ORGANOMERCURIALS SUCH AS MERCURIC ACETATE FOR TRANSPORT BY SERUM PROTEINS.ADDN OF 1000 OR 2000 PPM MERCURIC ACETATE TO DIET OF RATS FOR 15 DAYS STIMULATED THE IN VITRO OXIDATIVE CLEAVAGE OF ETHYL P-NITROPHENYL BENZENETHIOPHOSPHATE (EPN) & THE O-DEMETHYLATION OF P-NITROANISOLE BY LIVER MICROSOMES.SUBCUTANEOUS INJECTION OF 193 UMOL/KG OF (+)-PENICILLAMINE TWICE A DAY ON 6TH & 7TH DAYS AFTER INTRAMUSCULAR ADMIN OF 100 UG MERCURIC ACETATE INCR THE URINARY EXCRETION OF MERCURY IN RATS MORE THAN AN EQUIMOLAR DOSE OF N-ACETYL-(+)-PENICILLAMINE BUT LESS THAN THAT OF 48.3 UMOL/KG OF 2,3-DIMERCAPTOPROPANOL. ALL THIOL COMPLEXING AGENTS TESTED DECR KIDNEY CONTENT OF MERCURY & INCR LIVER & BLOOD CONCN.The protective activity of spironolactone (CAS 52-01-7) against mercuric acetate intoxication and the action of a spironolactone-mercuric acetate complex were studied on female Sprague-Dawley rats. Spironolactone was given 30 min after the toxic agent. It was found that spironolactone reversed the toxic effects of mercury, the mercury-spironolactone complex was much less toxic than mercuric acetate and its toxicity disappeared with the administration of spironolactone. A molecular mechanism for the protective action of spironolactone against mercury intoxication is proposed. The presence of both the steroidal skeleton and the thioacetyl group in the same molecule is necessary for the protection against mercury intoxication. |
| 健康影响 | Mercury mainly affects the nervous system. Exposure to high levels of metallic, inorganic, or organic mercury can permanently damage the brain, kidneys, and developing fetus. Effects on brain functioning may result in irritability, shyness, tremors, changes in vision or hearing, and memory problems. Acrodynia, a type of mercury poisoning in children, is characterized by pain and pink discoloration of the hands and feet. Mercury poisoning can also cause Hunter-Russell syndrome and Minamata disease. (L7) |
| 生态毒性数值 | LC50 Pimephales promelas (fathead minnows) 0.42 mg/l/48 hr, 0.53 mg/l/24 hr, 0.19 mg/l/96 hr /Conditions of bioassay not specified/ |
| 环境归趋 | INSECTICIDAL ACTION OF MERCURIC ACETATE APPLIED TO SOIL IS DUE TO METALLIC MERCURY IN THE GASEOUS STATE. FACTORS AFFECTING THE REDUCTION OF MERCURY SALTS TO METALLIC MERCURY ARE SOIL ORGANIC MATTER, MOISTURE, SOIL PH, & TEMPERATURE.METHYLMERCURY WAS FORMED AT VARIOUS INTERVALS, WHEN SOLN OF 1 NMOL OF MERCURIC ACETATE IN 100 ML WATER WAS IRRADIATE WITH BLACKLIGHT HAVING A SPECTRAL DISTRIBUTION SIMILAR TO SUNLIGHT. |
| 不良影响 | Neurotoxin - Sensorimotor |
| 暴露途径 | The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.Oral (L7)inhalation (L7)dermal (L7)" |
| 毒性概述 | High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through alterations in intracellular thiol status, mercury can promote oxidative stress, lipid peroxidation, mitochondrial dysfunction, and changes in heme metabolism. Mercury is known to bind to microsomal and mitochondrial enzymes, resulting in cell injury and death. For example, mercury is known to inhibit aquaporins, halting water flow across the cell membrane. It also inhibits the protein LCK, which causes decreased T-cell signalling and immune system depression. Mercury is also believed to inhibit neuronal excitability by acting on the postsynaptic neuronal membrane. It also affects the nervous system by inhibiting protein kinase C and alkaline phosphatase, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Mercury also produces an autoimmune response, likely by modification of major histocompatibility complex (MHC) class II molecules, self peptides, T-cell receptors, or cell-surface adhesion molecules. (L7, A8, A25, A26) |
| Signs and Symptoms | Sore throat. Cough.MAY BE ABSORBED! Redness.Metallic taste. Burning sensation. Abdominal pain. Vomiting. Diarrhoea.Common symptoms include peripheral neuropathy (presenting as paresthesia or itching, burning or pain), skin discoloration (pink cheeks, fingertips and toes), edema (swelling), and desquamation (dead skin peels off in layers). (A5) |
| ICSC Environmental Data | The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur in aquatic organisms. It is strongly advised not to let the chemical enter into the environment because it is persistent. |
| Medical Surveillance | Organic mercury exposure is best monitored by the measurement of total mercury (or the specific derivative) in whole blood. It has been recommended that the blood mercury level not be allowed to exceed 0.10 mg/l in workers exposed to organomercury compounds. /Organomercury compounds/ |
| Carcinogen Classification | No indication of carcinogenicity (not listed by IARC). (L135) |
| 大气标准 | Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Mercuric acetate is included on this list. |
| CERCLA 应报告数量 | Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Mercuric acetate is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 500/10,000 lbs. |
| 清洁水法要求 | Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Mercury and cmpd/ |
| 州饮用水指南 | (AZ) ARIZONA 3 ug/l /Mercury/ |
| Federal Drinking Water Standards | EPA 2 ug/l /Mercury/ |
| 联邦饮用水指南 | EPA 2 ug/l /Mercury/ |
| 水危害等级（WGK） | 3 |
| TSCA 清单状态 | TSCA listed |
| RTECS 号 | AI8575000 |
| 包装类别 | II |
| 危险类别 | 6.1Acute Tox. 1 DermalAcute Tox. 2 InhalationAcute Tox. 2 OralAquatic Acute 1Aquatic Chronic 1STOT RE 2 |
| 储存类别 | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
| 安全说明（S） | 13-28-36-45-60-61 |
| 海关编码 | 28521000 |
| 危险品标志 | T+,N |
| 危险类别码（R） | 26/27/28-33-50/53 |
| 毒害物质数据 | 1600-27-7(Hazardous Substances Data) |
| 运输编号（UN） | UN 1629 |
急性毒性
口服-大鼠 LD50: 40.9 毫克/公斤; 口服-小鼠 LD50: 23.9 毫克/公斤
职业标准
TLV-TWA 0.05 毫克 (汞)/立方米; STEL 0.10 毫克 (汞)/立方米
可燃性危险特性
受热分解剧毒含汞蒸气, 及可燃气体
储运特性
库房通风低温干燥; 与酸类, 食品分开储运
灭火剂
水, 二氧化碳, 干粉
用途与应用
用途
用作有机合成催化剂，用于医药工来和分析试剂。该品为剧毒品。
用途
用作分析试剂，也用于有机合成
制备与合成方法
生产方法
由乙酸与黄色氧化汞反应而得。将300ml30%的乙酸加热后，逐渐加入110g黄色氧化汞。溶解后趁热过滤，于暗处浓缩滤液至有结晶薄膜生成。经冷却，滤出结晶。母液再经浓缩结晶，得乙酸汞100g。