基本信息
- 标准SMILES
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cc3ccccc3cc2c1- InChIKey
ZITQUAHPZJHCJH-UHFFFAOYSA-N- 分子式
- C29H29Cl2N3O
- 平均分子量
- 506.5 g/mol
概述
a dopamine D3 receptor antagonist; structure in first source
名称与标识
- 首选名称
- Ngb-2849
- IUPAC
- N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]anthracene-2-carboxamide
名称与别名
NGB284926P8N956NZNGB-2849197242-80-1RefChem:927696NGB 2849UNII-26P8N956NZN-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyl)-2-anthracenecarboxamide2-Anthracenecarboxamide, N-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyl)-N-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl}-2-anthracenecarboxamideorb1739455SCHEMBL8183795
展开更多名称
ZITQUAHPZJHCJH-UHFFFAOYSA-N
数据库标识
- CAS
197242-80-1- PubChem CID
- 15411150
- UNII
- 26P8N956NZ
- Nikkaji
- J959.637B
性质
结构计算性质
- XLogP
- 7
- 极性表面积
- 35.6 Ų
- 氢键供体
- 1
- 氢键受体
- 3
- 可旋转键
- 7
- 重原子
- 35
- 形式电荷
- 0
- 复杂度
- 685
化学与工业
药理信息
MeSH Pharmacological Classification
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
相关反应
4 条
关联笔记
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